Epidemiologic and Bacterial Factors Facilitating Long-term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China
Despite ample healthcare resources, MDR-TB persists in urban areas due to both epidemiological and bacterial factors. The rpoB S450L mutation with compensatory mutations enhances transmission even in the absence of clear epidemiologic links. Effective control measures must address both epidemiological and bacterial factors.
Authors
- Xiaoyu Lu (ORCID: https://orcid.org/0000-0002-1330-5925)
- Yixiao Lu (ORCID: https://orcid.org/0000-0001-9299-7087)
- Jing Li (ORCID: https://orcid.org/0000-0001-6553-3914)
- Yating Ji (ORCID: https://orcid.org/0009-0005-6942-7867)
- Chongguang Yang (ORCID: https://orcid.org/0000-0001-8109-4974)
- Yangyi Zhang (ORCID: https://orcid.org/0000-0002-5465-6334)
- Yuan Jiang (ORCID: https://orcid.org/0000-0003-1211-6812)
- Minjuan Li
- Mingyu Gan (ORCID: https://orcid.org/0009-0008-4405-092X)
- Lili Wang (ORCID: https://orcid.org/0000-0002-6559-9910)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-9000-5021)
- Qingyun Liu (ORCID: https://orcid.org/0000-0002-2284-5050)
- Xin Shen (ORCID: https://orcid.org/0000-0002-8877-9762)
- Xi Zhu (ORCID: https://orcid.org/0000-0002-8272-4939)
- Ye Qi (ORCID: https://orcid.org/0009-0008-6015-9335)
- Renjie Hou (ORCID: https://orcid.org/0000-0003-2951-1632)
Institutions
- University of North Carolina at Chapel Hill (US)
- Sun Yat-sen University (CN)
- Yale University (US)
- Taiwan Centers for Disease Control (TW)
- Shanghai Municipal Center For Disease Control Prevention (CN)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1093/cid/ciaf313
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00