A new link between insulinoma and congenital glucose-galactose malabsorption
This is the first documented case of insulinoma in a patient with CGGM, suggesting a potential new link between glucose absorption disorders and pancreatic neuroendocrine tumors.The loss-of-function mutation in SGLT-1 due to an SLC5A1 gene mutation may impact pancreatic β-cell plasticity, potentially contributing to insulinoma development through altered glucose homeostasis.The patient's long-term high-fat, low-carbohydrate diet may have played a role in β-cell stimulation via increased levels of GLP-1 and GIP, both of which promote β-cell proliferation and survival.
Authors
- Wouter W. de Herder (ORCID: https://orcid.org/0000-0003-1463-5165)
- Remco T. P. van Cruchten (ORCID: https://orcid.org/0000-0002-2918-1488)
- Lodewijk A.A. Brosens (ORCID: https://orcid.org/0000-0003-1341-8994)
- Johannes Hofland (ORCID: https://orcid.org/0000-0003-0679-6209)
- Adorée M. van der Wiel
- Antonio Prinzi (ORCID: https://orcid.org/0009-0002-7021-9860)
- Marie‐Louise F. van Velthuysen (ORCID: https://orcid.org/0000-0003-0435-9494)
- Jelka Kuiper
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- University of Catania (IT)
- Ospedale Garibaldi (IT)
- Cancer Genomics Centre (NL)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Endocrine Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1530/eo-25-0030
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00