Comment on “Human scalp hair follicles can ‘taste’: chemosensory signalling via the bitter taste receptor TAS2R4 inhibits hair growth <i>ex vivo</i>”: reply from authors

In this response to Ume et al., we speculate about the potential connection between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and hair loss, suggesting that these drugs may impact hair follicle cycling through activation of the bitter taste receptor 2, member 4 (TAS2R4). We emphasize the need for targeted experiments to determine whether GLP-1RA directly affects human hair follicles via TAS2R4-mediated pathways.