Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts
This study presents the first single-cell atlas of rabbit scleral development, unveiling fibroblast heterogeneity, ECM remodeling mechanisms, and cross-species conserved features. These findings enhance our understanding of scleral biology and provide valuable insights for future research on ocular development and associated diseases, including myopia.
Authors
- Chengpeng Liang (ORCID: https://orcid.org/0000-0001-9180-6592)
- Qingqing Tang (ORCID: https://orcid.org/0009-0003-2401-0078)
- Shaorong Linghu
- Tingting Dan (ORCID: https://orcid.org/0000-0001-6936-2649)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-9027-9257)
- Huan Jiang (ORCID: https://orcid.org/0000-0001-5408-0454)
- Li Yang (ORCID: https://orcid.org/0000-0003-0456-4041)
- Xin Luo (ORCID: https://orcid.org/0000-0002-0523-7918)
- Rong Shi (ORCID: https://orcid.org/0000-0001-5884-6023)
- Fayuan Li
- Taixiang Liu
- Chengqi Gu
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1167/iovs.66.6.83
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61