The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H
The sialome of the human retina is altered in AMD. This may affect FH binding and, consequently, alternative complement pathway regulation.
Authors
- Hai Yu (ORCID: https://orcid.org/0000-0002-4378-0532)
- Jaclyn Swan (ORCID: https://orcid.org/0000-0003-1633-9239)
- Ajit Varki (ORCID: https://orcid.org/0000-0002-2206-975X)
- Sanjay Ram (ORCID: https://orcid.org/0000-0003-0058-9532)
- Anoopjit Singh Kooner (ORCID: https://orcid.org/0000-0003-1747-5689)
- Christopher B. Toomey (ORCID: https://orcid.org/0000-0003-0341-7787)
- Pascal Gagneux (ORCID: https://orcid.org/0000-0001-9599-9838)
- Yue Yuan (ORCID: https://orcid.org/0000-0003-3524-0576)
- Héctor Cuello (ORCID: https://orcid.org/0000-0002-5304-7545)
- Jutamas Shaughnessy (ORCID: https://orcid.org/0000-0003-0832-9954)
- Xi Chen (ORCID: https://orcid.org/0000-0002-3160-614X)
- Max Bergstrand
- Jesse Robie
Institutions
- University of Massachusetts Chan Medical School (US)
- University of California San Diego (US)
- University of California, Davis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1167/iovs.66.6.81
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- G. Harold and Leila Y. Mathers Foundation
- National Institutes of Health