Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases
Histological sections from normal-aged and early AMD eyes exhibit frequent tissue disruptions from post mortem handling, corresponding with regions of separation observed on OCT scans of various vitreoretinal diseases. Findings suggest that foveal areas of low mechanical stability may manifest as common ex vivo artifactual disruptions. Observing how foveal tissue breaks down post mortem may provide greater insight into the pathophysiology of different vitreoretinal diseases.
Authors
- Christine A. Curcio (ORCID: https://orcid.org/0000-0001-9769-1538)
- Rajeev H. Muni (ORCID: https://orcid.org/0000-0003-0465-6472)
- Jeffrey D. Messinger (ORCID: https://orcid.org/0000-0002-5975-3862)
- Isabela Martins Melo (ORCID: https://orcid.org/0000-0001-9330-828X)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- University of Alabama at Birmingham (US)
- Kensington Health (CA)
- Unity Health Toronto
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1167/iovs.66.6.82
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EyeSight Foundation of Alabama
- International Retinal Research Foundation
- Research to Prevent Blindness
- Edward N. and Della L. Thome Memorial Foundation
- National Institutes of Health