Phase 1 study and population PK/PD modeling of long-acting growth hormone, GB08, to guide pediatric dosing

GB08 provides notable advantages over traditional therapies, like short-acting GH, by enhancing treatment adherence and offering a potentially safer alternative. The findings from this study will guide dosing strategies for Phase 2 trial in children with GHD.

Authors

Jiang Zhu (ORCID: https://orcid.org/0000-0001-9940-2496)
Suofu Qin (ORCID: https://orcid.org/0000-0002-3323-8846)
Wei Shang (ORCID: https://orcid.org/0000-0002-0086-0436)
Jiajun Xu (ORCID: https://orcid.org/0000-0001-5010-2986)
Wen He (ORCID: https://orcid.org/0000-0001-6119-971X)
Hengxin Peng
Yanqing Lin

Institutions

WuXi AppTec (China) (CN)
Chengdu Fifth People's Hospital (CN)
Centre for Research and Development (ZW)

Publication Details

Journal: European Journal of Endocrinology
Published: 2025-06-17
DOI: https://doi.org/10.1093/ejendo/lvaf131
Primary Topic: Growth Hormone and Insulin-like Growth Factors
Type: article
Field-Weighted Citation Impact: 0.00

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article

Phase 1 study and population PK/PD modeling of long-acting growth hormone, GB08, to guide pediatric dosing

Jiang Zhu, Suofu Qin, Wei Shang, Jiajun Xu et al.

Jun 17, 2025

European Journal of Endocrinology

Growth Hormone and Insulin-like Growth Factors

article

Phase 1 study and population PK/PD modeling of long-acting growth hormone, GB08, to guide pediatric dosing

Jiang Zhu, Suofu Qin, Wei Shang, Jiajun Xu, Wen He, Hengxin Peng, Yanqing Lin

June 17, 2025article en

Abstract

GB08 provides notable advantages over traditional therapies, like short-acting GH, by enhancing treatment adherence and offering a potentially safer alternative. The findings from this study will guide dosing strategies for Phase 2 trial in children with GHD.

European Journal of EndocrinologyVol. 193(1)

WuXi AppTec (China) (CN), Chengdu Fifth People's Hospital (CN), Centre for Research and Development (ZW)

Good health and well-being

Openalex Percentile: Top 78%

Growth Hormone and Insulin-like Growth Factors

DOI Source OpenAlex

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