Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results

Objective: Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) exhibit a wide range of symptoms. Urodynamics-pressure flow study (UD-PFS) results may show that these patients have urgency, decreased bladder capacity, and pelvic pain worsening as the volume increases. UD-PFS examinations may contribute to analyzing the pathophysiology of lower urinary tract symptoms (LUTS). This study aimed to evaluate the demographic and clinical findings of IC/BPS patients and the results of UD-PFS examinations. Methods: The data of 132 IC/BPS patients between 2010 and 2020 were examined retrospectively, and UD-PFS was applied to 63 patients whose LUTS did not benefit from medical treatment. The patients' clinical and demographic data and UD-PFS findings were evaluated separately. Results: Of the patients who underwent UD-PFS, 7 were men, and 56 were women. The first urine sensation in UD was 74.0 ± 32.22 cc, and the maximum cystometric capacity was 288.4 ± 181.2 cc. Seven patients had a hypo-compliant bladder, and 42 had a normo-compliant bladder. In PFS, Qmax and maximum detrusor pressure in the voiding phase were 18.87 ± 8.21 mL/sec and 33.93 ± 14.78 cmH2O, respectively. Stress urinary incontinence was detected in 7 patients. For detrusor function, neurogenic detrusor overactivity was detected in 18 patients, and normal UD-PFS was detected in 45 patients, whereas reflexive detrusor was not observed. Cystoscopy revealed Hunner's ulcer in 7 patients. Conclusion: Urodynamic variables associated with early sensations, first urge, intense desire, and a reduced maximum cystometric capacity were significantly related to the severity of the IC/BPS symptoms. Urodynamic testing is not often a definitive diagnostic method for IC/BPS, although it may assist in the diagnosis process.