Engineered Lipid Coronas for Gold Nanoparticle-Based Bioorthogonal Catalysis
Bioorthogonal catalysis provides a powerful biomedical tool for controlled 'turn-on' activation of prodrugs and pro-dyes. Gold-based catalysts are highly selective and nontoxic; however, they are susceptible to deactivation by serum proteins and biogenic thiols. We present here a strategy that protects gold nanoparticle (AuNP) catalysts with a lipid corona, enabling bioorthogonal catalysis in biological environments. The modular nature of the lipid corona enables tuning of the surface charge, membrane fluidity, and PEG content. The stability and activity of these lipid-coated AuNPs was demonstrated by successfully converting inactive propargylated doxorubicin to the active drug in cancer cells.
Authors
- William Ndugire (ORCID: https://orcid.org/0000-0001-7818-4274)
- Cristina‐Maria Hirschbiegel (ORCID: https://orcid.org/0000-0003-2835-513X)
- Avijit Maity (ORCID: https://orcid.org/0009-0008-3972-8820)
- Alexander E. Ribbe (ORCID: https://orcid.org/0000-0002-9924-3429)
- Mohini Ghorpade
- Anjan Chakraborty (ORCID: https://orcid.org/0000-0001-5564-0679)
- Vincent M. Rotello (ORCID: https://orcid.org/0000-0002-5184-5439)
- Soham Chakraborty (ORCID: https://orcid.org/0000-0002-0846-4390)
- Aarohi Gupta (ORCID: https://orcid.org/0000-0003-1303-1159)
Institutions
- University of Massachusetts Amherst (US)
- Indian Institute of Technology Gandhinagar (IN)
- Indian Institute of Technology Indore (IN)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1021/acs.nanolett.5c02523
- Citations
- 3
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- United States - India Educational Foundation
- National Institutes of Health