Neoadjuvant PD-1 blockade induces the autophagy of immune cells: a new target for synergistic therapy of recurrent glioblastoma
L + M cells may represent critical immune components involved in autophagy induced by neoadjuvant PD-1 blockade. The interactions between HLA-DRA and CD4, as well as between GZMA and F2R, are crucial for modulating immune responses. Moreover, ribavirin, targeting CXCL8 and IL6, has the potential to enhance the efficacy of neoadjuvant PD-1 blockade.
Authors
- Zhongxiu Wu
- Ting Sun (ORCID: https://orcid.org/0000-0001-7251-0366)
- Zixue Xuan (ORCID: https://orcid.org/0000-0002-6296-4062)
- Qingxia Zhu (ORCID: https://orcid.org/0000-0003-1347-4021)
- Shuilian Zheng
- Kai Wang (ORCID: https://orcid.org/0000-0003-4529-2134)
- Jinying Jiang (ORCID: https://orcid.org/0000-0003-4650-5875)
- Hongying Zhao
Institutions
- Southwest Medical University (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102119
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Science and Technology Project of Zhejiang Province