B cells are not drivers of stromal cell activation during acute CNS infection
Neither B cell-derived LTβ or B cells are primary drivers of stromal cell activation networks in the CNS following mCoV infection. Although supplementary agonist mediated LTβR engagement confirmed a role for LTβ in enhancing PDPN and lymphoid chemokine expression, it impeded T cell migration to the CNS parenchyma and viral control. Our data overall indicate that stromal cells can integrate LTβR signals to tune their activation, but that LTβ is not necessarily essential and can even dysregulate protective antiviral T cell functions.
Authors
- Antoine Louveau (ORCID: https://orcid.org/0000-0003-2094-2735)
- Cornelia C. Bergmann (ORCID: https://orcid.org/0000-0003-1319-402X)
- Elyse M. Brozost
- Alexei V. Tumanov (ORCID: https://orcid.org/0000-0001-6042-0152)
- Mihyun Hwang (ORCID: https://orcid.org/0000-0003-2639-0265)
- Suhyun Oh (ORCID: https://orcid.org/0000-0002-6373-8833)
- Brendan T. Boylan
Institutions
- Cleveland Clinic (US)
- The University of Texas at San Antonio Health Science Center (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1186/s12974-025-03491-7
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Institutes of Health