A Rare Case of Cold Antibody-Mediated Autoimmune Haemolytic Anaemia in Early Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by autoantibody production, leading to multiorgan inflammation and tissue damage. Autoimmune haemolytic anaemia (AIHA) is a recognised haematologic complication of SLE. This report describes a 16-year-old female who presented with four weeks of generalised weakness, polyarthralgia, recurrent syncopal episodes, and Raynaud's phenomenon. This case highlights the diagnostic challenges of SLE presenting with AIHA, underscoring the importance of prompt, comprehensive autoimmune and haematologic evaluation in adolescents with unexplained anaemia and multi-system involvement.