TRIM16 Mediates K63-Linked Ubiquitination of DAB2 to Facilitate Vascular Calcification
Our study for the first time demonstrates that E3 ubiquitin ligase TRIM16 catalyzes K63-ubiquitination of the endocytic adaptor DAB2, leading to endocytosis of integrin β1 and activation of FAK-STAT3 signaling, and subsequently exacerbates vascular calcification, suggesting that TRIM16-DAB2 axis is a promising therapeutic target for vascular calcification.
Authors
- Jing‐Song Ou (ORCID: https://orcid.org/0000-0001-5517-3142)
- Li Li (ORCID: https://orcid.org/0009-0009-8857-1900)
- Liyun Feng (ORCID: https://orcid.org/0009-0009-9025-9254)
- Yuanzhi Ye (ORCID: https://orcid.org/0009-0003-9455-7597)
- Qingchun Liang (ORCID: https://orcid.org/0000-0001-9318-2357)
- Lihe Lu (ORCID: https://orcid.org/0000-0003-4518-3325)
- Jianyun Yan (ORCID: https://orcid.org/0000-0002-6962-1169)
- Zixi Zhang
- Zirong Lan (ORCID: https://orcid.org/0009-0004-7086-8996)
- Xiuli Zhang (ORCID: https://orcid.org/0000-0002-2478-356X)
- An Chen (ORCID: https://orcid.org/0000-0001-7607-977X)
- Fang Liu (ORCID: https://orcid.org/0000-0002-3832-8058)
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- National Health and Family Planning Commission (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Zimmerman Associates (United States) (US)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Hi-Z Technology (United States) (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1161/circresaha.125.326520
- Citations
- 6
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 4.84