Lactylation of HADHA Promotes Sepsis-Induced Myocardial Depression
This study reveals the significant impact of lactylation on cardiomyocyte metabolism. Lactate-induced HADHA lactylation disturbs cardiomyocyte mitochondrial function and metabolism and promotes sepsis-induced cardiac dysfunction. These findings inform the development of new therapeutic targets for sepsis-induced myocardial depression.
Authors
- Tie‐Ning Zhang (ORCID: https://orcid.org/0000-0003-4954-5370)
- Ri Wen (ORCID: https://orcid.org/0000-0002-7974-2132)
- Qi‐Jun Wu (ORCID: https://orcid.org/0000-0001-9421-5114)
- Ni Yang (ORCID: https://orcid.org/0000-0003-0167-5205)
- Xiaolu Shi (ORCID: https://orcid.org/0000-0002-5351-0894)
- Wanshan Ning (ORCID: https://orcid.org/0000-0002-1410-7891)
- Yue Li (ORCID: https://orcid.org/0000-0001-5603-104X)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-8058-8005)
- Chunfeng Liu (ORCID: https://orcid.org/0000-0001-5360-616X)
- Xinmei Huang (ORCID: https://orcid.org/0000-0002-7540-7361)
- Ting‐Ting Gong
- Yuhang Yang (ORCID: https://orcid.org/0000-0002-6294-6622)
- Yong-Ping Liu
- Fang-Hua Liu
- Linus Li (ORCID: https://orcid.org/0009-0006-5687-4446)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1161/circresaha.124.325708
- Citations
- 17
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 23.60