Regulatory roles of three-dimensional structures of chromatin domains
These findings suggest a model of gene regulation that involves positioning active cis-regulatory elements on domain surfaces. We also find that disease-associated non-coding variants are enriched on domain surfaces.
Authors
- Qin Cao (ORCID: https://orcid.org/0000-0002-3106-562X)
- Savio Ho-Chit Chow (ORCID: https://orcid.org/0000-0001-8994-8727)
- Chiara Nicoletti (ORCID: https://orcid.org/0000-0002-0872-6506)
- Danny Leung
- Huating Wang (ORCID: https://orcid.org/0000-0001-5474-2905)
- Prem Puri (ORCID: https://orcid.org/0000-0003-4964-0095)
- Kevin Y. Yip (ORCID: https://orcid.org/0000-0001-5516-9944)
- Kelly Yichen Li (ORCID: https://orcid.org/0000-0001-7377-5729)
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong University of Science and Technology (HK)
- Discovery Institute (US)
- Shatin Hospital (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Genome biology
- Published
- 2025-06-27
- DOI
- https://doi.org/10.1186/s13059-025-03659-7
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- California Institute for Regenerative Medicine
- National Natural Science Foundation of China
- Research Grants Council, University Grants Committee
- Chinese University of Hong Kong
- National Institutes of Health
- National Institute on Aging
- National Cancer Institute