Effectiveness of venetoclax based therapy in t(11;14) multiple myeloma with extensive extramedullary disease: a case report

Extramedullary disease in patients with newly diagnosed multiple myeloma is rare and, despite the abundance of new therapeutic options, is still associated with a dismal prognosis, classifying as an unmet clinical need. Here, we report the case of a young woman diagnosed with multiple myeloma and extensive extramedullary disease characterised by diffuse lymph node involvement. The patient received multiple chemotherapy regimens proving to be refractory to all of them and ultimately benefited from salvage therapy with Venetoclax combination therapy, with a complete disappearance of the extramedullary manifestations. This case proves the effectiveness of Venetoclax in t(11;14) myeloma with extramedullary involvement.