SORBS1 Knockdown Resists S/G2 Arrest and Apoptosis Caused by Polyphyllin H-Induced DNA Damage in Pancreatic Cancer
SORBS1 knockdown counteracts PPH-mediated S/G2 arrest and apoptosis by alleviating DNA damage in pancreatic cancer. These findings highlight SORBS1 as a critical modulator of PPH's therapeutic potential, linking its expression to chemoresistance mechanisms.
Authors
- Xiaofeng Yuan (ORCID: https://orcid.org/0000-0002-4890-4813)
- Fei Fang (ORCID: https://orcid.org/0009-0007-4011-9742)
- Yuye Xue (ORCID: https://orcid.org/0000-0002-5432-8103)
- Xinxin Hu
- Guang Cheng (ORCID: https://orcid.org/0000-0002-6860-4420)
- Shuangwu Yang
- Yuefei Zhou (ORCID: https://orcid.org/0000-0002-5371-298X)
- Pengcheng Qiu (ORCID: https://orcid.org/0000-0002-4826-4094)
- Yongqiang Zhang (ORCID: https://orcid.org/0000-0003-2214-6812)
- Jie Li (ORCID: https://orcid.org/0000-0002-7501-2503)
- Haifeng Tang (ORCID: https://orcid.org/0000-0003-4299-8705)
- Hailong Yuan
- Yunyang Lu
Institutions
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.064454
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00