Triplex formation-mediated fluorescence sensing of single bulge nucleotide-containing double-stranded RNAs using thiazole orange base surrogate-carrying PNAs
Fluorescence sensing of single bulge-containing double-stranded RNAs was achieved using a triplex forming peptide nucleic acid (PNA) carrying a thiazole orange (TO) base surrogate, where the TO base surrogate facing the bulged nucleotide exhibited a light-up response through triplex formation between the PNA sequence and target purine tracts in dsRNA.
Authors
- Eriks Rozners (ORCID: https://orcid.org/0000-0001-7649-0040)
- Seiichi Nishizawa (ORCID: https://orcid.org/0000-0001-6303-2999)
- Yusuke Sato (ORCID: https://orcid.org/0000-0002-5824-1654)
- Tianxue Han (ORCID: https://orcid.org/0000-0002-6090-7662)
Institutions
- Binghamton University (US)
- Tohoku University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02960k
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.81