Acute Bullous Disease in Polymyalgia Rheumatica

Polymyalgia rheumatica (PMR) is a common inflammatory condition affecting elderly patients, often presenting with non-specific symptoms that complicate diagnosis. We report the case of a 75-year-old female with a history of PMR and multiple comorbidities, admitted for dysphagia and vesiculobullous skin and mucosal lesions. Despite inconclusive histopathological findings and limited access to specific autoantibody testing, the clinical presentation raised suspicion of a bullous autoimmune dermatosis, possibly drug-induced. The patient responded favorably to immunosuppressive and antimicrobial therapy. This case highlights the diagnostic challenges in overlapping autoimmune syndromes and underscores the importance of interdisciplinary management in complex immunomodulated patients.