Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells

This study demonstrates a liposome-targeted and accelerated CRISPR strategy for specific response of miR-21 within MCF-7 cells. Targeting was achieved with the help of modification of the MUC1 aptamer. MnO<sub>2</sub> NS could be used as both a delivery vehicle and an accelerator for the CRISPR system, and finally to achieve spatially selective imaging of miR-21.

Authors

Xibin Chen
Yingshu Guo (ORCID: https://orcid.org/0000-0002-6926-6152)
Wenyue Zhang (ORCID: https://orcid.org/0000-0001-8181-8282)
Mengting Wu (ORCID: https://orcid.org/0000-0003-1652-0564)
Qingqing Zhang (ORCID: https://orcid.org/0000-0003-2628-7348)

Institutions

Qilu University of Technology (CN)
Shandong Academy of Sciences (CN)
Kai Biotech (South Korea) (KR)

Publication Details

Journal: Analytical Methods
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5ay00619h
Citations: 1
Primary Topic: CRISPR and Genetic Engineering
Type: article
Field-Weighted Citation Impact: 0.81

Funders

National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Qilu University of Technology

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article

Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells

Xibin Chen, Yingshu Guo, Wenyue Zhang, Mengting Wu et al.

Jan 1, 2025

1 citations

Analytical Methods

CRISPR and Genetic Engineering

0.81

article

Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells

Xibin Chen, Yingshu Guo, Wenyue Zhang, Mengting Wu, Qingqing Zhang

January 1, 2025article en

1 citations

Abstract

This study demonstrates a liposome-targeted and accelerated CRISPR strategy for specific response of miR-21 within MCF-7 cells. Targeting was achieved with the help of modification of the MUC1 aptamer. MnO<sub>2</sub> NS could be used as both a delivery vehicle and an accelerator for the CRISPR system, and finally to achieve spatially selective imaging of miR-21.

Analytical MethodsVol. 17(28)

Qilu University of Technology (CN), Shandong Academy of Sciences (CN), Kai Biotech (South Korea) (KR)

National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Qilu University of Technology

Openalex Percentile: Top 27%

CRISPR and Genetic Engineering

0.81

DOI Source OpenAlex

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Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells — Xibin Chen, Yingshu Guo, et al. · Analytical Methods (2025) | TGRS Research Map | TGRS