Levels of glucose and its metabolites, pancreatic hormones, and adiponectin in the Arctic population

The aim of the study was to identify the characteristics of carbohydrate metabolism, pancreatic hormones, and adiponectin in practically healthy Arctic population, depending on their ethnicity and lifestyle was conducted (populations of the local Caucasian population and aborigines (nomadic and sedentary) of the Arctic (Nenets) from 18 to 74 years old.). The lowest levels of glucose and insulin found in nomads against the background of increased proinsulin and adiponectin may indicate a decrease in the secretory activity of pancreatic beta cells and an improvement in insulin resistance; in sedentary aborigines, the predominance of anaerobic processes over aerobic ones is associated with a restriction of proinsulin production and is associated with an increase in insulin resistance with low levels of adiponectin, while in the local Caucasian population, insulin levels increase slightly while maintaining a higher level, which leads to an increased load on beta cells of the pancreas, causing an increase in adiponectin synthesis.