The effect of elevated and physiological concentrations of catecholamines on the formation of immunoglobulins in healthy individuals of the northern territories of the Russian Federation

The aim of the study was to study the effect of elevated and physiological concentrations of catecholamines on the formation of immune responses in residents of the northern territories of the Russian Federation. Thus, it has been established for the first time that practically healthy residents of the European North of the Russian Federation experience changes in the content of catecholamines and immunological parameters. An increase in the average dopamine content and a slight increase in the average IdM content was found. Studies have shown that patients have a tendency to increase the content of IgE immunoglobulin. In addition, abnormally high concentrations of IdM and elevated concentrations of IgG were detected. There was also a slight increase in the concentrations of cells capable of proliferation (CD10+). These changes correlate with the impact of negative climatic factors. Such factors include violation of the light regime and low temperatures, which provoke a chronic state of stress in the body and, as a result, increased stress on the immune system. This phenomenon leads to a malfunction of the immune system and accelerated physiological wear of the body, which can become a predisposing factor for the development of various diseases.