The influence of diet and nutrition stereotypes on the biological age of the indigenous population of the Republic of Sakha (Yakutia)

The study is devoted to assessing the impact of nutrition on accelerating or slowing down biological age in the indigenous population of Yakutia. The study involved 84 participants aged 18 to 89 years living in the central region of Yakutia. The average age of respondents was 58.0 (21.1) years. To analyze the food composition, the frequency questionnaire containing 30 questions were used. Using K-means method of the cluster analysis, two types of the nutrition were identified among the respondents. We assessed the age acceleration, calculating using three biological clock models: Horvath DNAm, Hannum DNAm, GrimAge in these groups of participants. Binary logistic regression showed that the odds of slowing biological ages increased with a moderate diet for Hannum DNAm by 6.3 times, Horvath DNAm by 21 times, and GrimAge by 15.8 times. The frequent overeating had a negative impact on the biological age of respondents. The frequency of consumption of dairy, fried, canned, salted products, and processed meat statistically significantly affected biological age. Acceleration of epigenetic age was observed in respondents with nutritional errors in the form of overeating and frequent consumption of easily digestible, high-calorie, canned foods.