Advances in Experimental Research on the Effects of Diverse Acupuncture Modalities on Animal Models of Rheumatoid Arthritis

类风湿性关节炎是常见的慢性疾病，发病率及致残率较高，因此其发病机制和治疗的研究尤为重要。近年来，临床上针灸治疗类风湿性关节炎取得了较大的进展，为明确不同针灸疗法治疗类风湿关节炎的机制，越来越多的研究者开展了不同针灸疗法对类风湿性关节炎动物模型影响的实验研究。本文通过检索近10年来不同针灸疗法对类风湿性关节炎动物模型影响的实验研究文献，结果显示针灸治疗可通过降低血清中的致炎因子，调节辅助型T细胞与调节型T细胞的平衡，或抑制滑膜组织NF-κB通路的表达等机制缓解类风湿性关节炎动物的关节炎症，从而减轻下肢肿胀程度，控制疾病进展。笔者通过对相关文献的归纳总结，以期为类风湿性关节炎动物实验研究和临床研究的完善提供理论依据和思路。Rheumatoid arthritis is a common chronic disease with a high incidence and disability rate, so the study of its pathogenesis and treatment is particularly important. In recent years, great progress has been made in the treatment of rheumatoid arthritis by acupuncture and moxibustion, and more and more researchers have carried out experimental studies on the effects of different acupuncture therapies on animal models of rheumatoid arthritis in order to clarify the mechanism of different acupuncture therapies in the treatment of rheumatoid arthritis. In this paper, we searched the experimental literature on the effects of different acupuncture therapies on animal models of rheumatoid arthritis in the past 10 years, and the results showed that acupuncture treatment could alleviate joint inflammation in rheumatoid arthritis animals by reducing inflammatory factors in serum, regulating the balance between helper T cells and regulatory T cells, or inhibiting the expression of NF-κB pathway in synovial tissue, thereby reducing the degree of swelling of the lower limbs and controlling the progression of the disease. This paper summarizes the relevant literature, in order to provide a theoretical basis and ideas for the improvement of animal experimental research and clinical research on rheumatoid arthritis.