Exploring the Treatment of Premature Ovarian Failure from the Small Intestine Based on Intestinal Flora

卵巢早衰(Premature Ovarian Failure, POF)是指女性在40岁之前因多种因素引发卵巢功能过早衰退的病理现象，其具体致病机理尚未完全阐明。现有研究表明，肠道菌群可能通过复杂的信号通路和作用靶点参与调控POF的进程，且有临床实践提示，通过调节小肠功能可改善肠道菌群生态平衡。然而，针对通过小肠调理途径优化肠道菌群以延缓卵巢衰老的作用机制，目前相关研究仍较为匮乏。基于此，本文以肠道菌群失衡为切入点，尝试从中医理论中小肠功能调节的视角出发，探索其对POF的干预作用，以期揭示中医调理小肠防治POF的潜在作用机制。Premature Ovarian Failure (POF) is a pathological phenomenon in which ovarian function declines prematurely before the age of 40 years due to a variety of factors, and its specific pathogenesis has not been fully elucidated. Existing studies have shown that the intestinal flora may be involved in the regulation of POF through complex signaling pathways and targets, and clinical practice suggests that the ecological balance of intestinal flora can be improved by regulating the function of the small intestine. However, there is still a lack of research on the mechanism of optimizing the gut flora to delay ovarian aging through small intestinal regulation. Based on this, this article takes the imbalance of intestinal flora as an entry point, and tries to explore the interventional effect on POF from the perspective of regulating the function of the small intestine in Chinese medicine theory, with a view to revealing the potential mechanism of Chinese medicine in regulating the small intestine for the prevention and treatment of POF.