Comparison of treatment costs for pancreatoduodenectomy depending on the sensitivity of flora to perioperatively used antibiotics

AIM. To estimate treatment costs depending on the sensitivity of the bacterial flora to perioperative antibiotics (PA) in patients undergoing pancreaticoduo- denectomy (PDR). MATERIALS AND METHODS. This retrospective study included patients who underwent PDR at the Moscow Clinical Research Center named after A. S. Loginov. 108 patients met the inclusion criteria; they were divided into two groups: patients with bile flora resistant to PA and patients with bile flora sen- sitive to PA. Subsequently, the course of the postoperative period was assessed: the incidence of complications in the study groups, including SSI, du- ration of hospitalization, assessment of the costs of diagnosis and treatment, as well as drug provision. The source for calculating the costs of diagnosis and treatment was the official Price List of the at the A. S. Loginov Moscow Clinical Research Center in 2024. Cost estimates for medicines were made according to the state register of maximum selling prices of manufacturers included in the list of vital and essential medicines. Statistical data analysis was carried out using the statistical package R 3.4.2 (USA). The study used methods of descriptive statistics, the Mann-Whitney U test to compare two independent samples, the chi-square test and Fisher’s exact test to analyze contingency tables. CONCLUSION. In cases of a personalized approach to the selection of an antibacterial drug for perioperative use during PDR, the risk of SSI can be significantly reduced and the costs of a completed case of medical care can be reduced.