Morphometric Analysis of Fibroblast Nuclei in Women's Breast Stroma from 60 Years

Introduction: Aging is a physiological process that reaches all organs and produces histological alterations characteristic in them. The female mammary glands undergo changes because of the passage of time. The changes that the populations of fibroblasts have mainly regarding their number linked to aging have been studied but there are few studies linked to nuclear changes in aging fibroblasts and even less those belonging to the stroma of the mammary glands of older adults. Objectives: Characterize the perimeter area volume and shape factor in fibroblasts nuclei from healthy mammary glands in women aged 60 years and older. Methods: To characterize the healthy mammary glands in 60 -year -old women and a serial study in killed women who did not have benign or malignant lesions of the organ was carried out. All examined by the Department of Pathological Anatomy of the Vladimir Ilich Lenin Provincial Hospital in Holguín in the period from September 2018 to September 2019. For better assessment, the sample of studies was divided into two age groups from 60 to 75 years old and over 75 years. Results: Both the area and volume perimeter and the form factor of the nuclei of the fibroblasts of the breast stroma are lower in women over 75 years Conclusions: The size and shape of the fibroblast nuclei in the healthy mammary glands are affected with age being smaller and elongated in women over 75 years old.