A <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris–</i> Optimized Episomal Plasmid–Induced Cas9-Editing System Reveals the Direct Impact of the S639F-Encoding <i>FKS1</i> Mutation
These data demonstrate the potential of our EPIC system in its ability to introduce SNPs in multiple C auris clade backgrounds while revealing the direct impact of the S639F-encoding FKS1 mutation on echinocandin resistance.
Authors
- Laura A. Doorley (ORCID: https://orcid.org/0000-0002-1695-9561)
- Jeffrey M. Rybak (ORCID: https://orcid.org/0000-0002-9317-0935)
- Sarah J Jones
- Vanessa Meza-Perez (ORCID: https://orcid.org/0000-0002-6828-5618)
Institutions
- St. Jude Children's Research Hospital (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1093/infdis/jiaf285
- Citations
- 6
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 8.38
Funders
- St. Jude Children's Research Hospital
- American Lebanese Syrian Associated Charities
- National Cancer Institute