Single-cell transcriptomic landscape indicates the potential role of immunotherapy in metastatic pancreatic angiosarcoma
Our findings outlined an immunosuppressive and angiogenic tumor ecosystem in pancreatic angiosarcoma liver metastasis, suggesting that pancreatic angiosarcoma may be insensitive to most targeted therapies. Conversely, immunotherapies targeting LAG3, PD-L1, and CD86 (e.g. isatuximab, Opdualag, and abatacept) and anti-angiogenic agents may be therapeutically effective and worthy of subsequent exploration.
Authors
- Xiaoxuan Lin (ORCID: https://orcid.org/0000-0002-4668-9101)
- Sui Peng (ORCID: https://orcid.org/0009-0002-8645-9551)
- Yubin Xie (ORCID: https://orcid.org/0000-0002-3566-4849)
- Luohai Chen (ORCID: https://orcid.org/0000-0003-3510-5921)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-1207-2573)
- Man Liu (ORCID: https://orcid.org/0000-0001-7411-6274)
- Minhu Chen (ORCID: https://orcid.org/0000-0001-8181-0846)
- Zhirong Zeng
- Yizhen Yang
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf046
- Primary Topic
- Vascular Tumors and Angiosarcomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province