Comparative acute toxicity of intravenous paclitaxel and sirolimus in rats
Both substances showed similar and acceptable tolerability after high single-dose intravenous treatment. The results of this study do not indicate safety concerns that would preclude the use of sirolimus as an active ingredient on balloon catheters as an alternative to paclitaxel.
Authors
- Ulrich Speck (ORCID: https://orcid.org/0000-0003-2174-2081)
- Tobias Haase (ORCID: https://orcid.org/0000-0002-7220-602X)
- Jing Pei Xie (ORCID: https://orcid.org/0000-0002-5545-5489)
- Denise Schuett
Institutions
- Humboldt-Universität zu Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Current Research in Toxicology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.crtox.2025.100248
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00