An esterase-sensitive persulfide/hydrogen sulfide generating fluorogenic probe enhances antioxidant response
Hydrogen sulfide (H<sub>2</sub>S) and sulfane sulfur species such as persulfides and polysulfides protect the cells from oxidative stress and are central to the endogenous antioxidant response. Here, we designed and developed a tool that is cleaved by esterase to generate phenacylthiol, which is an artificial substrate for 3-mercaptopyruvate sulfurtransferase (3-MST) and non-electrophilic lactone as a by-product. The esterase-sensitive persulfide generator enhances H<sub>2</sub>S and sulfane sulfur and protects chondrocytes from the lethality induced by elevated reactive oxygen species (ROS).
Authors
- Rachit Agarwal (ORCID: https://orcid.org/0000-0001-5703-4461)
- Ankan Ghosh (ORCID: https://orcid.org/0000-0002-1876-8910)
- Akshi Vashistha (ORCID: https://orcid.org/0000-0002-5352-8306)
- Harinath Chakrapani (ORCID: https://orcid.org/0000-0002-7267-0906)
- Babu Nand Choudhary (ORCID: https://orcid.org/0009-0002-4634-379X)
Institutions
- Indian Institute of Science Education and Research Pune (IN)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01523e
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Science and Engineering Research Board