Bromodomain protein 4 inhibitor JQ-1 alleviates hepatic ischemia-reperfusion injury by blocking the NLRP3/caspase-1 pathway
JQ-1 has potential as a pre-clinical emergency therapy for hepatic I/R injury. Its ability to inhibit BRD4 and modulate the inflammatory response in Kupffer cells offers a promising avenue for future clinical intervention.
Authors
- Weihua Gong (ORCID: https://orcid.org/0000-0002-3221-4316)
- Li Wang
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- World Journal of Emergency Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5847/wjem.j.1920-8642.2025.081
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00