The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis
Uremic conditions aggravate AS development in mice by inducing valvular fibrosis and macrophage infiltration. IS is involved in this process and stimulates monocyte differentiation and adhesion to the valvular endothelium. On a cellular level, we hypothesize that IS-mediated NKD2 induction leads to a calcifying and inflammatory response in VICs.
Authors
- Ansgar Ackerschott (ORCID: https://orcid.org/0000-0001-6473-2399)
- Frederik Dethloff
- Georg Nickenig
- Isabel Göbel
- Patrick Giavalisco (ORCID: https://orcid.org/0000-0002-4636-1827)
- Andreas Zietzer (ORCID: https://orcid.org/0000-0001-5759-7627)
- Felix Jansen (ORCID: https://orcid.org/0000-0001-6962-5330)
- Laurine Reese (ORCID: https://orcid.org/0000-0003-4810-3976)
- Marta Stei
- Thomas Beiert (ORCID: https://orcid.org/0000-0001-5398-403X)
- Christian Kurts (ORCID: https://orcid.org/0000-0002-6620-2401)
- Sebastian Zimmer (ORCID: https://orcid.org/0000-0002-1531-2088)
- Sven Thomas Niepmann (ORCID: https://orcid.org/0000-0001-8095-5824)
- Philip Düsing (ORCID: https://orcid.org/0000-0003-1394-6471)
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- Praxis für Humangenetik (DE)
- Institute of Molecular Medicine (IN)
- Max Planck Institute for Biology of Ageing (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1093/cvr/cvaf106
- Citations
- 5
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- RWTH Aachen University
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.