Ni-Catalyzed intramolecular cyclization of Baylis–Hillman adducts of 2-cyanoaniline towards 2,3-dihydroquinolin-4(1<i>H</i>)-ones
A Ni-catalyzed reductive cyclization of Baylis-Hillman adducts of 2-cyanoaniline is presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With <sup>i</sup>Pr-PyBOX as a chiral ligand, the catalytic enantioselective cyclization gave a moderate yield and ee.
Authors
- Jian Xiao (ORCID: https://orcid.org/0000-0003-4272-6865)
- Bi‐Qin Wang
- Xuanfeng Li
- Bin Chen (ORCID: https://orcid.org/0000-0002-9907-7002)
- Peng Cao (ORCID: https://orcid.org/0000-0001-8199-0015)
- Ping Hu
- T.‐F. LAI
- Minghui Xu (ORCID: https://orcid.org/0000-0003-3444-8332)
- Min Yang (ORCID: https://orcid.org/0000-0001-8338-9725)
- Hai‐Liang Ni (ORCID: https://orcid.org/0009-0000-1667-6214)
Institutions
- Chengdu Normal University (CN)
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00778j
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China