Long-term micro/nanoplastic ingestion promotes sepsis by worsening kidney damage: a transcriptomics and metabolomics study
Our study finds that smaller-sized plastics affect the survival of septic mice by damaging and aggravating kidney injury. Multi-omics analysis has revealed that five genes—Srm, Pycr2, Arg2, Asns, and Psat1—may play key roles in this process.
Authors
- Yao Cheng (ORCID: https://orcid.org/0000-0003-1179-2886)
- Min Shao (ORCID: https://orcid.org/0000-0001-7307-5570)
- Yutao Zha
- Sijie Yu
- Yuanfang Cheng (ORCID: https://orcid.org/0000-0002-7200-1614)
- Ming Fang (ORCID: https://orcid.org/0000-0002-4103-2063)
- Nian Liu (ORCID: https://orcid.org/0000-0002-4108-7937)
- Heng Wang (ORCID: https://orcid.org/0009-0005-3957-4575)
- Jinsong Wang (ORCID: https://orcid.org/0000-0002-2526-6193)
- Xiaorui Han (ORCID: https://orcid.org/0000-0001-9510-4838)
- Yayun Wu
Institutions
- Anhui Medical University (CN)
- Anhui Business College (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Environmental Science Nano
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4en01206b
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- University Natural Science Research Project of Anhui Province