Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions
This study found greater diffusion time effects in ischemic regions with purportedly larger axons. Monte Carlo simulations further support that the pronounced OGSE-PGSE diffusivity differences are expected in large axons with high beading amplitude.
Authors
- Mar Lloret
- Paige Fairall
- Brian H Buck (ORCID: https://orcid.org/0000-0002-7984-6062)
- Thorsten Feiweier (ORCID: https://orcid.org/0009-0005-3537-9844)
- Robert Stobbe (ORCID: https://orcid.org/0000-0002-6223-5222)
- Christian Beaulieu (ORCID: https://orcid.org/0000-0002-2342-3298)
- Matthew D. Budde (ORCID: https://orcid.org/0000-0003-4769-5797)
- Ashfaq M Shuaib (ORCID: https://orcid.org/0000-0002-3380-7068)
- Mahesh Kate (ORCID: https://orcid.org/0000-0003-4794-2882)
- Kenneth Butcher (ORCID: https://orcid.org/0000-0002-0590-7918)
- Mi Zhou (ORCID: https://orcid.org/0009-0003-1009-3896)
- Derek Emery
Institutions
- University of Alberta (CA)
- Medical College of Wisconsin (US)
- UNSW Sydney (AU)
- Siemens Healthineers (Germany) (DE)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/mrm.30618
- Citations
- 2
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Heart and Stroke Foundation of Canada
- Canada Research Chairs
- China Scholarship Council