Role of amylin and leptin in diet-induced obesity-associated hepatic and renaldysfunction in mae sprague dawley Rats

This study investigated the effects of amylin (AMN) and leptin (LEP), individually and in combination, on diet-induced obesity (DIO) and its associated hepatic and renal dysfunction in male Sprague Dawley (SD) rats.High-fat diet (HFD) resulted in significant increases in body weight, triglycerides, total cholesterol, and markers of hepatic (AST and ALT) and renal dysfunction (urea, creatinine, and uric acid).Although AMN and LEP administration individually led to moderate improvements, their combined treatment (AMN+LEP) demonstrated superior efficacy, significantly reducing body weight, triglyceride levels, hepatic enzyme activities, and renal dysfunction markers.These findings suggest that the AMN+LEP combination therapy may be a promising strategy for managing obesity-induced metabolic and organ dysfunction.