The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
High estimated cardiorespiratory fitness (eCRF) is associated with a lesser likelihood of becoming AD biomarker positive.High eCRF did not alter biomarker accumulation in those positive for Alzheimer's disease (AD) pathology.High eCRF attenuated the relationship between AD biomarkers and cognitive decline.Innovative methods: Stratifying analyses by amyloid beta and tau status.
Authors
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Bradley Christian (ORCID: https://orcid.org/0000-0001-5072-3512)
- Dane B. Cook (ORCID: https://orcid.org/0000-0002-3992-4820)
- Catherine L. Gallagher (ORCID: https://orcid.org/0000-0002-1701-6362)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Yue Ma (ORCID: https://orcid.org/0000-0002-1980-7520)
- Brianne M. Breidenbach (ORCID: https://orcid.org/0000-0001-6366-9818)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Ira Driscoll (ORCID: https://orcid.org/0000-0002-1737-3343)
- Sarah Lose
- Cynthia M. Carlsson (ORCID: https://orcid.org/0000-0001-5743-1563)
- Matthew Glittenberg
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Mark A. Sager
- Sterling C. Johnson
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3298-6324)
- Adam J. Paulsen (ORCID: https://orcid.org/0000-0001-9919-0577)
Institutions
- University of Science and Technology of China (CN)
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Geriatric Research Education and Clinical Center (US)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- William S. Middleton Memorial Veterans Hospital (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70122
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Waisman Center
- National Institutes of Health
- National Institute on Aging
- NIH Office of the Director
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development