Cycloaddition of bicyclo[1.1.0]butanes with enamides for the efficient synthesis of 2-amino-bicyclo[2.1.1]hexanes
Here, we develop a mild and scalable approach for the synthesis of 2-amino-bicyclo[2.1.1]hexanes <i>via</i> Lewis acid-catalyzed (3+2) cycloaddition of bicyclo[1.1.0]butanes (BCBs) with enamides. The practicality of this methodology has been demonstrated by scale-up reactions and product modifications, providing highly valuable aniline bioisosteres and structurally complex three-dimensional cyclic amines.
Authors
- Huiyu Chen
- Shaoxiong Yang (ORCID: https://orcid.org/0000-0002-2082-6198)
- Yanren Zhu (ORCID: https://orcid.org/0000-0002-8680-7600)
- Enfan Pu
- Hongbin Zhang (ORCID: https://orcid.org/0000-0002-2516-2634)
- Jingbo Chen (ORCID: https://orcid.org/0000-0001-7223-7857)
- Yi Jin (ORCID: https://orcid.org/0000-0003-0149-2150)
- Fang Zhang
- P. Jiang (ORCID: https://orcid.org/0009-0009-0668-4662)
Institutions
- Yunnan University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02908b
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China