Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration
Collectively, our findings demonstrate that senescence impairs regeneration by altering macrophage metabolic adaptation and functions, providing novel insights into the interplay between aging and regenerative capacity.
Authors
- Farida Djouad
- Audrey Barthelaix
- Claudia Terraza‐Aguirre (ORCID: https://orcid.org/0000-0001-6851-6300)
- Marie Morille (ORCID: https://orcid.org/0000-0001-8224-7346)
- Candice Bohaud (ORCID: https://orcid.org/0000-0001-5066-2641)
- Christian Jørgensen (ORCID: https://orcid.org/0000-0001-6947-8094)
- Jérémy Salvador (ORCID: https://orcid.org/0000-0001-7684-4689)
- Miguel Godinho Ferreira (ORCID: https://orcid.org/0000-0002-8363-7183)
- Yalén Del Río-Jay
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Université de Montpellier (FR)
- Université Côte d'Azur (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Institut de Recherche sur le Cancer et le Vieillissement de Nice (FR)
Publication Details
- Journal
- Theranostics
- Published
- 2025-06-20
- DOI
- https://doi.org/10.7150/thno.111352
- Citations
- 3
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Université de Montpellier
- Foundation for Research in Rheumatology