Faster decline of very prodromal dementia with Lewy bodies when amyloid positive
Patients at a very prodromal stage, subjective cognitive impairment or mild cognitive impairment, had a clinical diagnosis of either prodromal Alzheimer's disease (Pro-AD), prodromal dementia with Lewy bodies (Pro-DLB), Pro-DLB+AD, or no diagnosis.Amyloid beta positive (Aβ+) patients had more functional decline, whatever the group.Aβ+ DLB patients (Pro-DLB and Pro-DLB+AD) had more global cognitive (Mini-Mental State Examination) decline.Aβ+ Pro-AD patients showed a greater volume decline of the left insula.
Authors
- Olivier Bousiges (ORCID: https://orcid.org/0000-0001-6786-3191)
- Cathérine Belin (ORCID: https://orcid.org/0000-0003-4975-4578)
- Clara Fischer (ORCID: https://orcid.org/0000-0001-6109-6315)
- Alix Ravier
- Benjamin Crétin
- Benoît Schorr (ORCID: https://orcid.org/0000-0001-6392-5068)
- Pierre Krolak‐Salmon (ORCID: https://orcid.org/0000-0001-7815-7022)
- Audrey Gabelle (ORCID: https://orcid.org/0000-0002-7648-9194)
- David Wallon (ORCID: https://orcid.org/0000-0002-2634-7198)
- Paulo Loureiro de Sousa (ORCID: https://orcid.org/0000-0001-6610-5997)
- Catherine Demuynck
- Nathalie Philippi
- Jean‐François Mangin (ORCID: https://orcid.org/0000-0002-1612-461X)
- Claire Roubaud‐Baudron (ORCID: https://orcid.org/0000-0003-0870-0979)
- Olivier Moreaud (ORCID: https://orcid.org/0000-0002-7004-8777)
- Izzie Jacques Namer (ORCID: https://orcid.org/0000-0003-1822-7759)
- Renaud David (ORCID: https://orcid.org/0009-0003-8746-5758)
- Geneviève Chêne (ORCID: https://orcid.org/0000-0002-8368-6460)
- Vincent Bouteloup (ORCID: https://orcid.org/0009-0008-9956-862X)
- Anne Botzung (ORCID: https://orcid.org/0000-0002-1582-5828)
- Frédéric Blanc (ORCID: https://orcid.org/0000-0002-6714-3247)
- Carole Dufouil
- Jean‐François Dartigues
- Mathilde Sauvée
- Mathieu Ceccaldi
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Candice Muller
- Marie‐Odile Habert
- Marie Chupin
- Florence Pasquier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Lille (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Sorbonne Université (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Roger Salengro (FR)
- Bordeaux Population Health (FR)
- Hôpital Fernand-Widal (FR)
- Hôpital Gui de Chauliac (FR)
- Hôpital Pellegrin (FR)
- CEA Paris-Saclay (FR)
- Hôpital Avicenne (FR)
- Hôpital Xavier Arnozan (FR)
- Cognition Behaviour Technology (FR)
- Hôpital de la Timone (FR)
- Centre d'Acquisition et de Traitement des Images (FR)
- Université de Rouen Normandie (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70141
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Université de Bordeaux
- Fondation Plan Alzheimer