Research Progress of PKM2 in Digestive System Diseases

M2型丙酮酸激酶(Pyruvate Kinase M2, PKM2)是丙酮酸激酶家族中的一种重要成员，广泛存在于多种细胞类型中。近年来的研究表明，PKM2不仅在糖酵解过程中发挥关键作用，还具有调节细胞代谢、增殖、凋亡及免疫反应等多重功能。在消化系统疾病的发生和发展中，PKM2的作用日益受到关注。本文重点总结了PKM2在消化系统恶性肿瘤和炎症性肠病中的研究进展，探讨其在疾病发生中的分子机制，分析其在消化系统疾病中的潜在治疗价值，尤其是PKM2作为靶向治疗策略的可能性。M2 pyruvate kinase (Pyruvate Kinase M2, PKM2) is an important member of the pyruvate kinase family, which is widely present in many cell types. Recent studies have shown that PKM2 not only plays a key role in glycolysis, but also has multiple functions in regulating cell metabolism, proliferation, apoptosis and immune response. Especially in the occurrence and development of digestive system diseases, the role of PKM2 has received increasing attention. In this paper, we focus on summarizing the research progress of PKM2 in digestive malignant tumors and inflammatory bowel disease, exploring its molecular mechanism in disease development, and analyzing its potential therapeutic value in digestive diseases, especially the possibility of PKM2 as a targeted therapeutic strategy.