Elucidating the Role of Gardeniae Fructus and Scutellariae Radix HerbPair in Alzheimer's Disease via Network Pharmacology: Emphasis onOxidative Stress, and the PI3K/Akt Pathway

Our study uncovered the therapeutic potential of the ZZ-HQ combination in addressing AD through multi-target mechanisms, particularly via modulation of the PI3K/Akt pathway and oxidative stress. These findings provide a scientific basis for the pharmacological effects of ZZ-HQ and offer valuable insights for further research on its potential application in AD treatment.

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Publication Details

Journal
Current Pharmaceutical Biotechnology
Published
2025-06-24
DOI
https://doi.org/10.2174/0113892010326797250422095516
Citations
1
Primary Topic
Computational Drug Discovery Methods
Type
article
Field-Weighted Citation Impact
1.50
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article

Elucidating the Role of Gardeniae Fructus and Scutellariae Radix HerbPair in Alzheimer's Disease via Network Pharmacology: Emphasis onOxidative Stress, and the PI3K/Akt Pathway

Qihui Huang, Min Zhu, Liang Ai, J. Ye et al.
1 citations
Current Pharmaceutical Biotechnology
Computational Drug Discovery Methods
1.50
article

Elucidating the Role of Gardeniae Fructus and Scutellariae Radix HerbPair in Alzheimer's Disease via Network Pharmacology: Emphasis onOxidative Stress, and the PI3K/Akt Pathway

Qihui Huang, Min Zhu, Liang Ai, J. Ye, Jia Wu
article en
1 citations

Abstract

Our study uncovered the therapeutic potential of the ZZ-HQ combination in addressing AD through multi-target mechanisms, particularly via modulation of the PI3K/Akt pathway and oxidative stress. These findings provide a scientific basis for the pharmacological effects of ZZ-HQ and offer valuable insights for further research on its potential application in AD treatment.

Current Pharmaceutical BiotechnologyVol. 26
Sun Yat-sen University (CN), Sun Yat-sen Memorial Hospital (CN)
Openalex Percentile: Top 16%
Computational Drug Discovery Methods
1.50
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