Elucidating the Role of Gardeniae Fructus and Scutellariae Radix HerbPair in Alzheimer's Disease via Network Pharmacology: Emphasis onOxidative Stress, and the PI3K/Akt Pathway
Our study uncovered the therapeutic potential of the ZZ-HQ combination in addressing AD through multi-target mechanisms, particularly via modulation of the PI3K/Akt pathway and oxidative stress. These findings provide a scientific basis for the pharmacological effects of ZZ-HQ and offer valuable insights for further research on its potential application in AD treatment.
Authors
- Qihui Huang
- Min Zhu (ORCID: https://orcid.org/0000-0002-5265-2006)
- Liang Ai
- J. Ye
- Jia Wu
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.2174/0113892010326797250422095516
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50