High-sensitivity C-reactive protein mediates age-related vascular dysfunction: the Rotterdam study
Systemic inflammation indexed by hsCRP appears to mediate and potentially contribute causally to age-related vascular stiffness, particularly in men. These findings support the role of inflammation in functional vascular ageing and suggest that anti-inflammatory strategies may complement lipid-lowering approaches in reducing cardiovascular risk.
Authors
- Bruno H. Stricker
- Fariba Ahmadizar (ORCID: https://orcid.org/0000-0002-6261-9445)
- Annique Claringbould (ORCID: https://orcid.org/0000-0002-9201-6557)
- A.H. Jan Danser (ORCID: https://orcid.org/0000-0002-5052-3585)
- Soroush Mohammadi Jouabadi (ORCID: https://orcid.org/0000-0002-5710-3057)
- Maryam Kavousi (ORCID: https://orcid.org/0000-0001-5976-6519)
- Anton J.M. Roks (ORCID: https://orcid.org/0000-0001-7155-1756)
Institutions
- Harvard University (US)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1093/eurjpc/zwaf370
- Citations
- 7
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 9.72