Cystic fibrosis and fertility: current state of the problem (literature review)

Cystic fibrosis (CF) is the most common autosomal recessive inherited disease affecting the respiratory tract, gastrointestinal tract, liver, pancreas, salivary and sweat glands, and reproductive system. The incidence of cystic fibrosis ranges from 1:2000 in Russia and is quite common among Europeans. For a long time, the life expectancy of patients with cystic fibrosis did not exceed 30–35 years, and therefore pregnancy and the birth of healthy children in women with cystic fibrosis were extremely rare. With the advent of effective antibacterial therapy, and then the introduction of selective modulators of cystic fibrosis receptors, these indicators improved. Data on the safe continuous use of selective cystic fibrosis receptor modulators during pregnancy are gradually accumulating worldwide. This makes us optimistic about the planning and implementation of reproductive function in women with cystic fibrosis.