The Anti-Angiogenic Effect of Microbotox on Rosacea Is Due to the Suppressed Secretion of VEGF by Mast Cells Resulting From Internalization of the MRGPRX2 Receptor
BoNT/A enhances LL37-mediated MRGPRX2 internalization in mast cells, thereby reducing VEGF secretion and neovascularization and improving facial flushing symptom in rosacea.
Authors
- Zhi-Kai Liao (ORCID: https://orcid.org/0009-0009-2261-2239)
- Bingqi Dong (ORCID: https://orcid.org/0009-0006-9380-4092)
- Tiechi Lei (ORCID: https://orcid.org/0000-0003-2304-827X)
- Lin-Xia Liu (ORCID: https://orcid.org/0009-0005-5610-8453)
- Jing Wan
- Yue Le (ORCID: https://orcid.org/0000-0002-0483-8420)
- Mo Geng
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Annals of Dermatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5021/ad.24.171
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China