The relationship between genetic predictors and ferritin levels in metabolic syndrome (Literature review)

Metabolic syndrome is defined as a pathological condition characterized by abdominal obesity, insulin resistance, hypertension and hyperlipidemia. Although the successful conquest of infectious diseases worldwide has been accomplished, this new non-communicable disease poses a serious threat to the health of the modern world.Hyperferritinemia in the pathogenesis of metabolic syndrome triggers a cascade of mechanisms involved in the development of insulin resistance, liver steatosis/fibrosis, etc. In the course of special studies, the role of five key genes in the development of hyperferritinemia has been proven: HFE (hemochromatosis), HJV (hemojuvelin), HAMP (antimicrobial peptide hepcidin), TfR2 (transferrin receptor 2) and FP (ferroportin).The determination of the relationship and gene predictors between hyperferritinemia and the components of metabolic syndrome contributes to the fact that doctors have now begun to provide personalized treatment for each patient.Key words: metabolic syndrome, hyperferritinemia, gene predictor, insulin resistance, gene polymorphism.