Utility of cardiac biomarkers (NT-proBNP and Hs-Troponin-T) in predicting mortality, cardiovascular and renal outcomes in patients with chronic kidney disease
In NDD-CKD patients, NT-proBNP and Hs-cTnT are predictors of all-cause mortality, MACE, and ESKD, independently of eGFR and uACR. Combining NT-proBNP and Hs-cTnT with eGFR and uACR outperformed risk prediction for ESKD compared to kidney biomarkers used alone or in combination.
Authors
- Darren Green (ORCID: https://orcid.org/0000-0002-9370-8176)
- Helen Alderson
- Sharmilee Rengarajan
- Senthil K. Vasan (ORCID: https://orcid.org/0000-0002-3630-6568)
- Nicolas Vuilleumier (ORCID: https://orcid.org/0000-0002-1122-438X)
- Rajkumar Chinnadurai (ORCID: https://orcid.org/0000-0003-3973-6595)
- Philip A. Kalra (ORCID: https://orcid.org/0000-0001-7652-1572)
Institutions
- University of Geneva (CH)
- Renal Association (GB)
- University Hospital of Geneva (CH)
- Salford Royal Hospital (GB)
- University Hospitals Geneva Medical Center (US)
- NIHR Manchester Biomedical Research Centre (GB)
- Geneva College (US)
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1159/000546489
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Institute for Health and Care Research
- Manchester Biomedical Research Centre