Atypical Spitz Tumor in a Pediatric Patient: A Case Report.

This case highlights the clinical, diagnostic, and management challenges of ASTs in pediatric patients. Although malignant potential is uncertain, ASTs often have an excellent prognosis with negative margins following WLE. In this case, IHC staining for PRAME and BRAF helped support the decision to defer SNL biopsy. This case underscores the importance of morphologic and molecular analysis to assess risk and guide management. Further research into molecular biomarkers may improve risk stratification and optimize treatment strategies for ASTs in pediatric patients.

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Journal
PubMed
Published
2025-05-01
Primary Topic
Chromatin Remodeling and Cancer
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article
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article

Atypical Spitz Tumor in a Pediatric Patient: A Case Report.

L. E. Christensen, Joseph H Kelly, Marcus L. Frohm
PubMed
Chromatin Remodeling and Cancer
article

Atypical Spitz Tumor in a Pediatric Patient: A Case Report.

L. E. Christensen, Joseph H Kelly, Marcus L. Frohm
article en

Abstract

This case highlights the clinical, diagnostic, and management challenges of ASTs in pediatric patients. Although malignant potential is uncertain, ASTs often have an excellent prognosis with negative margins following WLE. In this case, IHC staining for PRAME and BRAF helped support the decision to defer SNL biopsy. This case underscores the importance of morphologic and molecular analysis to assess risk and guide management. Further research into molecular biomarkers may improve risk stratification and optimize treatment strategies for ASTs in pediatric patients.

PubMedVol. 78(suppl 5)
University of South Dakota (US)
Openalex Percentile: Top 87%
Chromatin Remodeling and Cancer
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