Optimizing Transcranial Doppler Screening for Stroke Prevention in Young African Children With Sickle Cell Disease
TCD screening of young children with SCD is feasible, with low technical failure rates. Many children in our cohort had a conditional risk study, suggesting cerebral vasculopathy begins at a young age in some African children. Future large cohort studies should be undertaken to determine the incidence of conditional or high risk studies in African children ≤2 years with SCD to inform future guideline development for TCD screening.
Authors
- Clement Lupumpaula
- Peter Kabemba
- Jean Pongo Mbaka
- Taty Tshimanga
- Janet Simanguwa Chilima
- Nicole O’Brien
- Davin Ambitapio Musungufu
- Suzanna Mwanza (ORCID: https://orcid.org/0000-0001-8080-7215)
- M. Co
- Robert Tandjeka Ekandji
- Lisa Nkole Kafula
- Ludovic Mayindombe
- George Chagaluka
- Catherine Chunda‐Liyoka (ORCID: https://orcid.org/0000-0003-2393-4933)
- Tusekile Phiri
- Derby Tembo (ORCID: https://orcid.org/0000-0001-5220-5735)
- Sylvester June
- Peter Moons
- Florette Yumsa Mangwangu
Institutions
- Nationwide Children's Hospital (US)
- Kamuzu Central Hospital (MW)
- University Teaching Hospital (ZM)
- University of Kinshasa (CD)
- Université Evangélique en Afrique (CD)
- Queen Elizabeth Central Hospital (MW)
- The Ohio State University (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/pbc.31861
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Child Health and Human Development